Hearing Research誌に論文を発表

コモンマーモセットという小型のサルにおいて、無侵襲(体を傷つけない安全)な方法で脳波を記録する、独自の方法を開発して論文発表しました。

脳の病気や、脳の進化を調べる新しい方法論として、今後の活用が期待されます。

https://www.sciencedirect.com/science/article/pii/S0378595521000630

Kosuke Itoh, Haruhiko Iwaoki, Naho Konoike, Hironaka Igarashi, Katsuki Nakamura,
Noninvasive scalp recording of the middle latency responses and cortical auditory evoked potentials in the alert common marmoset,
Hearing Research, Volume 405, 2021, 108229, ISSN 0378-5955, https://doi.org/10.1016/j.heares.2021.108229.

Abstract: The common marmoset (Callithrix jacchus), a New World monkey, serves as a useful animal model in clinical and basic neuroscience. The present study recorded scalp auditory evoked potentials (AEP) in non-sedated common marmoset monkeys (n = 4) using a noninvasive method similar to that used in humans, and aimed to identify nonhuman primate correlates of the human AEP components. A pure tone stimulus was presented while electroencephalograms were recorded using up to 16 disk electrodes placed on the scalp and earlobes. Candidate homologues of two categories of the human AEP, namely, the middle latency responses (MLR; Na, Pa, Nb, and Pb) and the cortical auditory evoked potentials (CAEP; P1, N1, P2, N2, and the sustained potential, SP) were identified in the marmoset. These waves were labeled as CjNa, CjPa, CjNb, CjPb, CjP1, CjN1, CjP2, CjN2, and CjSP, where Cj stands for Callithrix jacchus. The last MLR component, CjPb, was identical to the first CAEP component, CjP1, similar to the relationship between Pb and P1 in humans. The peak latencies of the marmoset MLR and CAEP were generally shorter than in humans, which suggests a shorter integration time in neural processing. To our knowledge, the present study represents the first scalp recorded MLR and CAEP in the alert common marmoset. Further use of these recording methods would enable valid species comparisons of homologous brain indices between humans and animals.
Keywords: Nonhuman primates; Event-Related Potential (ERP); Auditory Evoked Potential (AEP); Auditory Late Response (ALR); Middle Latency Auditory Evoked Potential (MLAEP); Electroencephalogram (EEG)

京都大学霊長類研究所との共同研究です。

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